Search results for " case-control study"

showing 10 items of 22 documents

No association between the cystatin C gene polymorphism and Alzheimer's disease: a case-control study in an Italian population.

2005

Cystatin C is an amyloidogenic protein found together with beta-amyloid in cerebral arteriolar walls of both patients with Alzheimer's Disease (AD) and conghopilic amyloid angiopathy. Several findings implicate cystatin C in the pathogenesis of vascular diseases. Recent genetic association studies proposed cystatin C gene (CST3) as a susceptibility factor for AD, although other reports did not replicate this finding. We conducted a case-control study including 192 probable AD cases and 192 age- and sex-matched controls to test the association between CST3 and AD. Possible interaction between CST3 and age at onset of AD or apolipoprotein E (APOE) was also examined. No significant differences…

MaleApolipoprotein EGenotypeDiseasePathogenesisApolipoproteins EAlzheimer DiseaseGenotypeHumansGenetic Predisposition to DiseaseCystatin CAllele frequencyAllelesAgedGenetic associationAged 80 and overGeneticsGenomic LibraryPolymorphism GeneticbiologyKeywords: Alzheimer’s disease cystatin C apolipoprotein E case-control study polymorphismGeneral NeuroscienceCase-control studyGeneral MedicineMiddle AgedCystatinsPsychiatry and Mental healthClinical PsychologyItalyCystatin CCase-Control StudiesImmunologybiology.proteinSettore MED/26 - NeurologiaFemaleGeriatrics and Gerontology
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Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nest…

2011

The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41,440, 30-69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids were determined at baseline. The APOE polymorphism was sign…

AdultMaleApolipoprotein Emedicine.medical_specialtyAlcohol DrinkingGenotypeEndocrinology Diabetes and MetabolismSaturated fatClinical BiochemistryPopulationCoronary DiseaseBiochemistryGastroenterologyWhite PeopleApolipoproteins ERisk FactorsInternal medicineOdds RatiomedicineHumansLongitudinal StudieseducationMolecular BiologyAllelesAgededucation.field_of_studyPolymorphism GeneticNutrition and Dieteticsbusiness.industryFatty AcidsCase-control studyCholesterol LDLOdds ratioMiddle AgedDietEuropean Prospective Investigation into Cancer and NutritionEndocrinologySpainCase-Control StudiesMultivariate AnalysisNested case-control studySaturated fatty acidRegression AnalysisFemalebusinessThe Journal of Nutritional Biochemistry
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A nested case–control study: personal, social and environmental correlates of vigorous physical activity in adolescents with asthma

2014

Objective: Physical activity (PA) is associated with health benefits. Children and adolescents with asthma may be limited in their PA, particularly at vigorous intensity due to asthma symptoms or poor psychological adjustment to asthma. We aimed to investigate if self-perceived competence, enjoyment, support from others and social-physical environment were associated with vigorous physical activity (VPA) and secondarily to assess if such associations were modified by asthma and asthma severity. Methods: Data from a nested case–control study at 13 years of age within the birth-cohort Environment and Childhood Asthma Study were compiled from 95 participants with and 79 without asthma. The par…

MaleParentsPulmonary and Respiratory Medicinemedicine.medical_specialtyAdolescentHealth BehaviorcompetencePhysical activityEnvironmentSeverity of Illness IndexPeer GroupMetabolic equivalentsocial environmentSocial supportSex Factorsimmune system diseasesMetabolic EquivalentmedicineHumansImmunology and AllergyBody Weights and MeasuresChildExerciseCompetence (human resources)Asthmabusiness.industrySocial environmentsocial supportmedicine.diseaseFacultyAsthmaSelf Efficacyrespiratory tract diseasesPeer reviewCase-Control Studiesphychological adjustmentPediatrics Perinatology and Child HealthNested case-control studyPhysical therapyFemalehealth benefitsbusinessClinical psychologyJournal of Asthma
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Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-con…

2015

BACKGROUND Kaposi sarcoma (KS) is a complication of KS-associated herpesvirus (KSHV) infection. Other oncogenic viral infections and malignancies are associated with certain HLA alleles and their natural killer (NK) cell immunoglobulin-like receptor (KIR) ligands. We tested whether HLA-KIR influences the risk of KSHV infection or KS. METHODS In population-based case-control studies, we compared HLA class I and KIR gene frequencies in 250 classic (non-AIDS) KS cases, 280 KSHV-seropositive controls, and 576 KSHV-seronegative controls composing discovery and validation cohorts. Logistic regression was used to calculate sex- and age-adjusted odds ratios (ORs) and 95% confidence intervals. RESUL…

0301 basic medicineGenotypevirusescase-control studyPopulationchemical and pharmacologic phenomenaHuman leukocyte antigenBiologyLymphocyte ActivationSettore MED/42 - Igiene Generale E ApplicataMajor Articles and Brief Reports03 medical and health sciencesReceptors KIRnatural killer–cell immunoglobulin-like receptorsHLA AntigensRisk FactorsSeroepidemiologic Studieshuman leukocyte antigenGenotypeotorhinolaryngologic diseasesHLA-B AntigensHumansImmunology and AllergySeroprevalenceGenetic Predisposition to Diseasehuman geneticeducationSarcoma Kaposieducation.field_of_studyClassic Kaposi SarcomaCase-control studyvirus diseasesKaposi sarcomaOdds ratiomajor histocompatibility complex030104 developmental biologyInfectious DiseasesGene Expression RegulationItalyCase-Control StudiesItaly; Kaposi sarcoma; case-control study; human genetics; human leukocyte antigens; major histocompatibility complex; natural killer–cell immunoglobulin-like receptorsHerpesvirus 8 HumanImmunologyJournal of Infectious Diseases
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Occupational factors and risk of adult bone sarcomas:a multicentric case-control study in Europe

2006

International audience; We investigated the association between occupational factors and risk of bone sarcoma, a rare tumor with a largely unknown aetiology. A multicentric case-control study was conducted in 7 European countries in 1995-97. Ninety-six cases aged 35-69 years with a centrally reviewed diagnosis of bone sarcoma (68 chondrosarcomas and 28 osteosarcomas) were compared to 2,632 population (68%) or colon cancer (32%) controls. Subjects were interviewed to obtain information on occupational, medical and reproductive history, smoking and alcohol consumption and selected exposures including use of pesticides. Response proportions were 90% among cases and 66% among controls. Odds rat…

MaleCancer ResearchMESH: OsteosarcomaMESH: ReproductionMESH: Occupational Exposure0302 clinical medicineMESH: Risk FactorsRisk FactorsEpidemiologyadult bone sarcomasOdds Ratio030212 general & internal medicineeducation.field_of_studyOsteosarcomaMESH: Middle AgedReproductionResearch Support Non-U.S. Gov'tSmokingMESH: ChondrosarcomaMiddle AgedMESH: Bone NeoplasmsMESH: Interviews as TopicMESH: Case-Control Studies3. Good healthEuropeMulticenter StudyOncology030220 oncology & carcinogenesisColonic NeoplasmsFemaleSarcomamulticentric case-control studyAdultmedicine.medical_specialtyMESH: SmokingAlcohol DrinkingPopulationChondrosarcomaBone NeoplasmsBone SarcomaOccupational medicineInterviews as Topic03 medical and health sciencesInternal medicineOccupational ExposuremedicineJournal ArticlewoodworkersHumansComparative StudyRisk factoreducationMESH: Colonic NeoplasmsMESH: Humansbusiness.industryCase-control studyoccupational risk factorsMESH: AdultOdds ratiopesticidesmedicine.diseaseMESH: MaleMESH: Odds RatioSurgery[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieCase-Control Studies[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieMESH: EuropebusinessMESH: FemaleMESH: Alcohol Drinking
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Soluble transferrin receptor and risk of type 2 diabetes in the obese and nonobese.

2017

Background Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. Design A nested case–control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (…

Blood GlucoseMalemedicine.medical_specialtyWaistIronClinical BiochemistryPopulation030209 endocrinology & metabolismType 2 diabetes030204 cardiovascular system & hematologyDiet MediterraneanBiochemistryGastroenterology03 medical and health sciences0302 clinical medicineInterquartile rangeRisk FactorsInternal medicineReceptors TransferrinmedicineHumansObesityeducationSoluble transferrin receptorAgedAged 80 and overeducation.field_of_studybiologybusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseObesityDiabetes Mellitus Type 2Case-Control StudiesCohortNested case-control studybiology.proteinFemalebusinessBiomarkersEuropean journal of clinical investigation
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Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects　― Nested Case-Control Study in the Prevention With Mediterr…

2017

BACKGROUND: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results:The associations between TCL and CVD were evaluated in a case-control study nested within the "PREvención con DIeta MEDiterránea" (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analys…

MaleMetalls -- Efectes fisiològicsChromiumPREDIMED0301 basic medicineMediterranean diet010501 environmental sciencesDiet Mediterranean01 natural sciences03 medical and health sciencesMediterranean cookingRisk FactorsCuina mediterràniaHumansMedicineToenail biomarkerAged0105 earth and related environmental sciencesAged 80 and overDiabetis030109 nutrition & dieteticsMalalties cardiovascularsbusiness.industryDiabetesGeneral MedicineMiddle AgedAtencion primariaCardiovascular diseasePredimedDietCardiovascular DiseasesSpainCase-Control StudiesNested case-control studyDietaFemaleCardiology and Cardiovascular MedicinebusinessHumanitiesOlive oilCirculation Journal
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Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

2017

Background: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease duri…

Malecompuestos de metilmercurioTime Factorsmodelos logísticosMediterranean diethumanos030204 cardiovascular system & hematologyDiet MediterraneanRecommended Dietary AllowancesDieta mediterrània1471-22610302 clinical medicineRisk Factorsestudios prospectivosevaluación de riesgosOdds RatioOily fishWater Pollutants030212 general & internal medicineProspective StudiesToenail biomarkeruñasmediana edadCiències de la salutAged 80 and overeducation.field_of_studyBioquímica y tecnologíaanciano:Ciencias de la Salud::Salud pública [Materias Investigacion]dietaMALALTIES CARDIOVASCULARSMethylmercury CompoundsMiddle Agedcontaminantes del aguaCardiovascular diseaseCiencias de la saludcociente de probabilidades relativasBiochemistry and technologyCardiovascular DiseasesBody BurdenFemaleCardiology and Cardiovascular Medicinecantidad dietética recomendadaResearch ArticlePREDIMEDmedicine.medical_specialtyPopulationestudios de casos y controlesenfermedades cardiovasculareschemistry.chemical_elementFood ContaminationSistema cardiovascular malaltiesBioquímica i biotecnologiaRisk Assessment03 medical and health sciencesalimentos del marfactores de tiempoEnvironmental healthMediterranean dietmedicineHumansfactores de riesgoMercuri -- Toxicologiaanálisis multifactorialeducationCardivascular diseaseAgedbusiness.industryCase-control studyHealth sciencesOdds ratioMercuryProtective FactorsSurgeryMercury (element)DietLogistic ModelsFishchemistrySeafoodNailsSpainRelative riskCase-Control StudiesNested case-control studyMultivariate AnalysisbusinessWater Pollutants Chemicalcarga corporal
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Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

2019

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually.Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza.Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) again…

Maletest-negative case-control study0301 basic medicinePrevalenceInfluenza vaccine effectiveness test-negative case-control study national influenza surveillance network ItalySettore MED/42 - Igiene Generale E ApplicataInfluenza A Virus H1N1 Subtype0302 clinical medicineDrug DiscoveryEpidemiology030212 general & internal medicineChildInfluenza vaccine effectivenessAged 80 and overnational influenza surveillance networkAge Factorsvirus diseasesMiddle Aged3. Good healthVaccinationTreatment OutcomeItalyInfluenza VaccinesChild PreschoolMolecular MedicineFemaleInfluenza vaccine effectiveness; Italy; national influenza surveillance network; test-negative case-control studyAdultmedicine.medical_specialtyAdolescentInfluenza vaccineImmunologyContext (language use)VirusYoung Adult03 medical and health sciencesInternal medicineInfluenza HumanmedicineAnimalsHumansAgedPharmacologybusiness.industryInfluenza A Virus H3N2 SubtypeCase-control studyInfant030104 developmental biologyImmunizationCase-Control StudiesbusinessExpert Review of Vaccines
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Insulin and other antidiabetic drugs and hepatocellular carcinoma risk: a nested case-control study based on Italian healthcare utilization databases

2015

Purpose Insulin and other antidiabetic drugs may modulate hepatocellular carcinoma (HCC) risk in diabetics. Methods We have analyzed the role of various antidiabetic drugs on HCC in a nested case-control study using the healthcare utilization databases of the Lombardy Region in Italy. This included 190 diabetic subjects with a hospital discharge reporting a diagnosis of malignant HCC and 3772 diabetic control subjects matched to each case on sex, age, date at cohort entry, and duration of follow-up. Results Increased risks of HCC were found for use of insulin (odds ratio [OR] = 3.73, 95% confidence interval [CI] 2.52–5.51), sulfonylureas (OR = 1.39, 95%CI 0.98–1.99), and repaglinide (OR = 2…

DatabaseEpidemiologybusiness.industryInsulinmedicine.medical_treatmentOdds ratioPharmacoepidemiologymedicine.diseasecomputer.software_genreRepaglinideMetforminDiabetes mellitusNested case-control studyCohortmedicinePharmacology (medical)businesscomputermedicine.drugPharmacoepidemiology and Drug Safety
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